Dr. Astrid Schrammel-Gorren
Assistant Professor
Pharmacology & Toxicology; Institute for Pharmaceutical Sciences
University of Graz
Universitätsplatz 2
8010 Graz
Austria
T: 0043 316 380 5559
F: 0043 316 380 9890
E: This email address is being protected from spambots. You need JavaScript enabled to view it.
Research Interests
Our working group is interested in vascular NO/cGMP signaling in murine models of obesity.
Currently we are focussing to characterize cardiovascular dysfunction in mice lacking adipose triglyceride lipase (ATGL), a key enzyme of triglyceride catabolism.
In particular, we are interested in the role of cardiovascular oxidative stress mediated by NADPH oxidases.
In addition, the impact of perivascular adipose tissue on vascular function/dysfunction has become an additional research topic in our laboratory.
Selected Recent Publications
- Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, Zechner R, and Mayer B. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim. Biophys. Acta. 2013;1831(11):1600-08.
- Wölkart G, Beretta M, Wenzl MV, Stessel H, Schmidt K, Maeda N, Mayer B, and Schrammel A. Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency. Br J Pharmacol. 2013;168(8):1868-77.
- Neubauer R, Neubauer A, Wolkart G, Schwarzenegger C, Lang B, Schmidt K, Russwurm M, Koesling D, Gorren AC, Schrammel A, et al. Potent Inhibition of Aldehyde Dehydrogenase-2 by Diphenyleneiodonium: Focus on Nitroglycerin Bioactivation. Mol Pharmacol. 2013; 84(3):407-14.
- Wölkart G, Schrammel A, Dorffel K, Haemmerle G, Zechner R, and Mayer B. Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARalpha agonist. Br J Pharmacol. 2012;165(2):380-9.
