Home The Action Management Committee Peter Brouckaert (BE)


Prof. Dr. Peter Brouckaert, MD,PhD

Molecular Pathophysiology and Experimental Therapy Unit 
Department for Biomedical Molecular Biology 
Faculty of Sciences 
Ghent University 
Department of Molecular Biomedical Research 
Flanders Institute of Biotechnology (VIB)

Technologiepark 927
B-9052 Ghent
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Research Interests
Our research is focused on

  • molecular mechanisms of inflammatory  shock, and the role of the NO/cGMP axis and reactive oxygen species in  this, using mouse models;
  • target validation of soluble guanylate  cyclase (sGC) its isoforms and apo-sGC using mouse transgenic  technology; and
  • identification of new targets for vasculature  disrupting cancer treatment.

Selected Recent Publications

  • CAUWELS, A., BUYS, E.S., THOONEN, R., GEARY, L., DELANGHE, J., SHIVA,  S., AND BROUCKAERT, P.,  Nitrite protects against morbidity and mortality associated with TNF-  or LPS- induced shock in mice in an sGC dependent manner  J. Exp. Med., 206, 2915-2924, 2009
  • BUYS, E.S., SIPS, P., VERMEERSCH, P., RAHER, M.J., ROGGE, E., ICHINOSE,  F., DEWERCHIN, M., BLOCH, K.D., JANSSENS, S., BROUCKAERT, P. Gender specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice Cardiovasc. Res., 79, 179-186, 2008
  • NAGASAKA, Y., BUYS, E.S., SPAGNOLLI, E., STEINBICKER, A.U., HAYTON,  S.R., RAUWERDINK, K.M., BROUCKAERT, P, ZAPOL, W.M., BLOCH, K.D.Soluble guanylate cyclase α1 is required for the cardioprotective  effects of inhaled nitric oxide  Am. J. Physiol. Heart Circ. Phys., 300, H1477-1483, 2011



POLICY STATEMENT: Biomedicine and Molecular Biosciences Action BM1005 is funded by COST, through its implementing agent the European Science Foundation.