Prof. Dr. Peter Brouckaert, MD,PhD
Molecular Pathophysiology and Experimental Therapy Unit
Department for Biomedical Molecular Biology
Faculty of Sciences
Ghent University
Department of Molecular Biomedical Research
Flanders Institute of Biotechnology (VIB)
Technologiepark 927
B-9052 Ghent
Belgium
This email address is being protected from spambots. You need JavaScript enabled to view it.
Research Interests
Our research is focused on
- molecular mechanisms of inflammatory shock, and the role of the NO/cGMP axis and reactive oxygen species in this, using mouse models;
- target validation of soluble guanylate cyclase (sGC) its isoforms and apo-sGC using mouse transgenic technology; and
- identification of new targets for vasculature disrupting cancer treatment.
Selected Recent Publications
- CAUWELS, A., BUYS, E.S., THOONEN, R., GEARY, L., DELANGHE, J., SHIVA, S., AND BROUCKAERT, P., Nitrite protects against morbidity and mortality associated with TNF- or LPS- induced shock in mice in an sGC dependent manner J. Exp. Med., 206, 2915-2924, 2009
- BUYS, E.S., SIPS, P., VERMEERSCH, P., RAHER, M.J., ROGGE, E., ICHINOSE, F., DEWERCHIN, M., BLOCH, K.D., JANSSENS, S., BROUCKAERT, P. Gender specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice Cardiovasc. Res., 79, 179-186, 2008
- NAGASAKA, Y., BUYS, E.S., SPAGNOLLI, E., STEINBICKER, A.U., HAYTON, S.R., RAUWERDINK, K.M., BROUCKAERT, P, ZAPOL, W.M., BLOCH, K.D.Soluble guanylate cyclase α1 is required for the cardioprotective effects of inhaled nitric oxide Am. J. Physiol. Heart Circ. Phys., 300, H1477-1483, 2011
