Prof. Viktor Kozich
Head of Department (name of department: Institute of Inherited Metabolic Disorders)
Charles University in Prague- First Faculty of Medicine
Katerinska 32
121 08 Prague
Czech Republic
T: +420224967679
F: +420224967168
E: This email address is being protected from spambots. You need JavaScript enabled to view it.
Research Interests
- homocysteine and sulfur amino acids metabolism
- inborn errors of sulfur amino acid metabolism and B-vitamins
- hydrogen sulfide
- cystathionine beta-synthase
- cystathionase
Selected Recent Publications
- Vozdek R; Hnízda A; Krijt J; Šerá L; KožichV. Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis. BBA - Proteins and Proteomics 2013 (in press, DOI: 10.1016/j.bbapap.2013.09.020)
- Pravenec M, Kozich V, Krijt J, Sokolová J, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Oliyarnyk O, Kazdová L, Kurtz TW. Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats. Am J Hypertens. 2013 Jan;26(1):135-40. doi: 10.1093/ajh/hps015
- Roman HB, Hirschberger LL, Krijt J, Valli A, Kožich V, Stipanuk MH. The Cysteine Dioxgenase Knockout Mouse: Altered Cysteine Metabolism in Nonhepatic Tissues Leads to Excess H2S/HS- Production and Evidence of Pancreatic and Lung Toxicity. Antioxid Redox Signal. 2013 Mar 19
- Hnízda A, Majtan T, Liu L, Pey AL, Carpenter JF, Kodíček M, Kožich V, Kraus JP. Conformational properties of nine purified cystathionine β-synthase mutants. Biochemistry. 2012 Jun 12;51(23):4755-63. doi: 10.1021/bi300435e
- Vozdek R, Hnízda A, Krijt J, Kostrouchová M, Kožich V. Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1. Biochem J. 2012 Apr 15;443(2):535-47. doi: 10.1042/BJ20111478.
