Jaap A. Joles, DVM, PhD

Associate Professor
Dept. of Nephrology & Hypertension,
University Medical Centre Utrecht,
T: +31 30 253 5269
F: +31 30 254 4932
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

Research Interests

  • Gasotransmitters in vascular and renal physiology
  • Regenerative medicine in chronic kidney disease
  • Pathogenesis of cardiorenal syndrome
  • Neurogenic hypertension
  • Minituarized artificial kidney

Selected Recent Publications

  • Wester M, Simonis F, Gerritsen KG, Boer WH, Wodzig WK, Kooman JP, Joles JA.
    A regenerable potassium and phosphate sorbent system to enhance dialysis efficacy and device portability: an in vitro study.
    Nephrol Dial Transplant. 2013 Sep;28(9):2364-71. doi: 10.1093/ndt/gft205. PubMed PMID: 23825104.
  • van Koppen A, Joles JA, van Balkom BW, Lim SK, de Kleijn D, Giles RH, Verhaar MC.
    Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease.
    PLoS One. 2012;7(6):e38746. doi: 10.1371/journal.pone.0038746. PubMed PMID: 22723882; PubMed Central PMCID: PMC3378606.
  • Koeners MP, van Faassen EE, Wesseling S, de Sain-van der Velden M, Koomans HA,Braam B, Joles JA.
    Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects.
    Hypertension. 2007 Dec;50(6):1077-84. PubMed PMID: 17938381.
  • Bevers LM, Braam B, Post JA, van Zonneveld AJ, Rabelink TJ, Koomans HA,Verhaar MC, Joles JA.
    Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase.
    Hypertension. 2006 Jan;47(1):87-94. PubMed PMID: 16344367.
  • Wesseling S, Ishola DA Jr, Joles JA, Bluyssen HA, Koomans HA, Braam B.
    Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor.
    Am J Physiol Renal Physiol. 2005 Jun;288(6):F1191-200. PubMed PMID: 15727990.




POLICY STATEMENT: Biomedicine and Molecular Biosciences Action BM1005 is funded by COST, through its implementing agent the European Science Foundation.