European Network on Gasotransmitters

Joint Publications by COST members

2015 Publications

1. Cortese-Krott MM, Kuhnle GG, Dyson A, Fernandez BO, Grman M, DuMond JF, Barrow MP, McLeod G, Nakagawa H, Ondrias K, Nagy P, King SB, Saavedra JE, Keefer LK, Singer M, Kelm M, Butler AR, Feelisch M. Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.Proc Natl Acad Sci U S A. 2015 Jul 29. pii: 201509277. 

2. Berenyiova A, Grman M, Mijuskovic A, Stasko A, Misak A, Nagy P, Ondriasova E, Cacanyiova S, Brezova V, Feelisch M, Ondrias K. The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants.Nitric Oxide. 2015 Apr 30;46:123-30. doi: 10.1016/j.niox.2014.12.008. Epub 2014 Dec 18.

3. Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, Wood ME, Lacinova L, Ondrias K, Whiteman M. Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels.Nitric Oxide. 2015 Apr 30;46:131-44. doi: 10.1016/j.niox.2014.12.012. 

4. Bibli SI, Yang G, Zhou Z, Wang R, Topouzis S, Papapetropoulos A. Role of cGMP in hydrogen sulfide signaling.Nitric Oxide. 2015 Apr 30;46:7-13. doi: 10.1016/j.niox.2014.12.004. 

5. Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M,  Papapetropoulos A. The role of H2S bioavailability in endothelial dysfunction. Trends Pharmacol Sci. 2015 Jun 9. pii: S0165-6147(15)00097-8. doi: 10.1016/j.tips.2015.05.007. 

6. Glynos C, Toumpanakis D, Loverdos K, Karavana V, Zhou Z, Magkou C, Dettoraki M, Perlikos F, Pavlidou A, Kotsikoris V, Topouzis S, Theocharis SE, Brouckaert P, Giannis A, Papapetropoulos A, Vassilakopoulos T. Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation.Am J Respir Cell Mol Biol. 2015 Jun;52(6):762-71. doi: 10.1165/rcmb.2014-0092OC.

7. Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A. Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.Cardiovasc Res. 2015 Jun 1;106(3):432-42. doi: 10.1093/cvr/cvv129. Epub 2015 Apr 13.

8. Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME. Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.Handb Exp Pharmacol. 2015;230:337-63. doi: 10.1007/978-3-319-18144-8_17.

9. Babu D, Leclercq G, Goossens V, Remijsen Q, Vandenabeele P, Motterlini R, Lefebvre RA. Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells. Toxicol Appl Pharmacol. 2015; pii: S0041-008X(15)30032-6. doi: 10.1016/j.taap.2015.07.007

10. Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chlopicki S. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels.Biochim Biophys Acta. 2015 Jul 14;1847(10):1297-1309. doi: 10.1016/j.bbabio.2015.07.004. 

2014 Publications

1. Cortese-Krott MM, Fernandez BO, Santos JL, Mergia E, Grman M, Nagy P, Kelm M, Butler A, Feelisch M. Nitrosopersulfide (SSNO(-)) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide.Redox Biol. 2014 Jan 11;2:234-44. doi: 10.1016/j.redox.2013.12.031.

2. Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J, Fukuto JM. Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.Free Radic Biol Med. 2014 Dec;77:82-94. doi: 10.1016/j.freeradbiomed.2014.09.007. Epub 2014 Sep 16.

3. Cosyns SM, Huyghe L, Thoonen R, Stasch JP, Brouckaert P, Lefebvre RA. Influence of cinaciguat on gastrointestinal motility in apo-sGC mice.Neurogastroenterol Motil. 2014 Nov;26(11):1573-85. doi: 10.1111/nmo.12424. Epub 2014 Sep 8.

4. Bucci M, Vellecco V, Cantalupo A, Brancaleone V, Zhou Z, Evangelista S, Calderone V, Papapetropoulos A, Cirino G. Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition. Cardiovasc Res. 2014 Apr 1;102(1):138-47. doi: 10.1093/cvr/cvu026. Epub 2014 Feb 5.

5. Módis K, Bos EM, Calzia E, van Goor H, Coletta C, Papapetropoulos A, Hellmich MR, Radermacher P, Bouillaud F, Szabo C. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects.Br J Pharmacol. 2014 Apr;171(8):2123-46. doi: 10.1111/bph.12368.

2013 Publications

1. A. Asimakopoulou, P. Panopoulos, CT. Chasapis, C. Coletta, Z. Zhou, G. Cirino, A. Giannis, C. Szabo, G.A. Spyroulias, A. Papapetropoulos, Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE). Br J Pharmacol. 2013 Mar 14. doi: 10.1111/bph.12171. [Epub ahead of print] 
2. SM. Cosyns, I. Dhaese, R. Thoonen, ES. Buys, A. Vral, P. Brouckaert, R.A. Lefebvre.Heme deficiency of soluble guanylate cyclase induces gastroparesis. Neurogastroenterol Motil. 2013; 25(5):339-52. doi: 10.1111/nmo.12120
3. A. Martínez-Ruiz, I.M. Araújo, A. Izquierdo-Álvarez, P. Hernansanz-Agustín, S. Lamas, J.M. Serrador. Specificity in S-nitrosylation: a short-range mechanism for NO signaling? Antioxid Redox Signal. 2013 Jan 4. [Epub ahead of print]
4. Carlos C. Romão and Helena L. A. Vieira. Metal Carbonyls for CO-based Therapies: challenges and successes. in "Organometallic Chemistry: Recent Advances, ICOMC Silver/Gold Jubilee Book", A. J. L. Pombeiro Editor, J. Wiley, 2013 (in press) ISBN: 9781118510148
5. C. Glynos, LL Dupont, T Vassilakopoulos, A Papapetropoulos, P. Brouckaert, A Giannis, GF Joos, KR Bracke, GG Brusselle The Role of Soluble Guanylyl Cyclase in Chronic Obstructive Pulmonary Disease. .Am J Respir Crit Care Med. 2013 Jul 10. [Epub ahead of print]
6. K. Módis, E. Bos, E. Calzia, H. van Goor, Harry; C. Coletta, A. Papapetropoulos, M. Hellmich, P. Radermacher; F. Bouillaud, C. Szabo. Regulation of Mitochondrial Function by Hydrogen Sulfide. Part II. Pathophysiological and Therapeutic Aspects Br. J. Pharmacol In press
7. M. von Wantoch Rekowski, V. Kumar, Z. Zhou, J. Moschner, A. Marazioti, M. Bantzi, G. A. Spyroulias, Focco van den Akker, A. Giannis, A. Papapetropoulos. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. J. Med. Chem. In press

2012 Publications

1. Z. Zhou*,  M. von Wantoch Rekowski*, C. Coletta, C. Szabo, M. Bucci, G. Cirino, S. Topouzis, A. Papapetropoulos*, A Giannis*. Thioglycine and L-thiovaline: biologically active H₂S-donors. Bioorg. Med. Chem. 2012, 20:2675-8
2. Ι. Andreadou, D. Farmakis, Ε. Prokovas, F. Sigala, Α. Zoga, K. Spyridaki, A. Papapetropoulos, Μ. Anastasiou-Nana, D. Th. Kremastinos, Ε.Κ.Iliodromitis. Short-term statin administration in hypercholesterolemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase and nitro-oxidative stress. Cardiovasc Res. 2012, 94:501-9
3. D. Babu, S.J. Soenen, K. Raemdonck, G. Leclercq, O. De Backer, R. Motterlini, R.A. Lefebvre. TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells. Curr Pharm Des. 2012, 18: 4414-442
4. M. Bucci, A. Papapetropoulos, V. Vellecco, Z. Zhou, A. Zaid, P. Giannogonas, A. Cantalupo, S. Dhayade, KP. Karalis, R. Wang, R. Feil, G. Cirino. cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation. PLoS One. 2012;7(12):e53319. doi: 10.1371/journal.pone.0053319.

2011 Publications

1. A. Marazioti, M. Bucci, C. Coletta, V. Vellecco, P. Baskaran, C. Szabo, G. Cirino, AR. Marques, B. Guerreiro, AM. Gonçalves, JD. Seixas, A. Beuve, CC. Romão, A. Papapetropoulos.  Inhibition of Nitric Oxide-Stimulated Vasorelaxation by Carbon Monoxide-Releasing Molecules. Arterioscler Thromb Vasc Biol. 2011, 31:2570-6

COST participants are underlined