European Network on Gasotransmitters

Hot Papers of September 2015-January 2016

Hot Papers of the month July-August 2014

• Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ. Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content. J Biol Chem. 2014 May 30;289(22):15259-71. doi: 10.1074/jbc.M114.559393.
• Steiger C, Lühmann T, Meinel L. Oral drug delivery of therapeutic gases - Carbon monoxide release for gastrointestinal diseases.J Control Release. 2014 Jun 24;189C:46-53. doi: 10.1016/j.jconrel.2014.06.025. 
• Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR. H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381
• Lavin B, Gómez M, Pello OM, Castejon B, Piedras MJ, Saura M, Zaragoza C. Nitric Oxide Prevents Aortic Neointimal Hyperplasia by Controlling Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1739-46. doi: 10.1161/ATVBAHA.114.303866. 
• Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014 Jun 2;124(6):2464-71. doi: 10.1172/JCI70731.
• Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, Vigneshwar N, Mukhopadhyay ND, Kukreja RC, Abbate A, Salloum FN.Induction of MicroRNA-21 With Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice. Circ Cardiovasc Genet. 2014 Jun;7(3):311-20. doi: 10.1161/CIRCGENETICS.113.000381. 
• Xie ZZ, Shi MM, Xie L, Wu ZY, Li G, Hua F, Bian JS. Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide. Antioxid Redox Signal. 2014 Jun 26.
• Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7606-11. doi: 10.1073/pnas.1321232111. 
• Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E, Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide O, Tadele E, Brandes RP, Grimminger J, Klepetko W, Jaksch P, Rodriguez-Roisin R, Seeger W, Grimminger F, Barberà JA. Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema.Am J Respir Crit Care Med. 2014 Jun 1;189(11):1359-73. doi: 10.1164/rccm.201311-2037OC.