The “4th International Conference on the Biology of Hydrogen Sulfide” will be held in Naples on June 3- 5, 2016. The last three Conferences were held in Shanghai, Atlanta and Kyoto with considerable success. I hope to keep up with this tradition making the 2016 conference an exciting forum for information exchange, debate and collaboration on H₂S research.

• Yi B, Ozerova M, Zhang GX, Yan G, Huang S, Sun J. Post-Transcriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Polypyrimidine Tract-Binding Protein 1. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2153-60. doi: 10.1161/ATVBAHA.115.305750.
• Lundberg JO, Gladwin MT, Weitzberg E. Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discov. 2015 Sep;14(9):623-41. doi: 10.1038/nrd4623.
• Saha S, Chakraborty PK, Xiong X, Dwivedi SK, Mustafi SB, Leigh NR, Ramchandran R, Mukherjee P, Bhattacharya R. Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration. FASEB J. 2015 Sep 24. pii: fj.15-278648.
• Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482.
• Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H. Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):78-85. doi: 10.1161/ATVBAHA.115.306263.
• Godo S, Sawada A, Saito H, Ikeda S, Enkhjargal B, Suzuki K, Tanaka S, Shimokawa H. Disruption of Physiological Balance Between Nitric Oxide and Endothelium-Dependent Hyperpolarization Impairs Cardiovascular Homeostasis in Mice. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):97-107. doi: 10.1161/ATVBAHA.115.306499.
• Szabo C. Gasotransmitters in cancer: from pathophysiology to experimental therapy. Nat Rev Drug Discov. 2015 Dec 18. doi: 10.1038/nrd.2015.1.
• Velmurugan GV, Huang H, Sun H, Candela J, Jaiswal MK, Beaman KD, Yamashita M, Prakriya M, White C. Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production. Sci Signal. 2015 Dec 15;8(407):ra128. doi: 10.1126/scisignal.aac7135.
• Abraham NG, Junge JM, Drummond GS. Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome. Trends Pharmacol Sci. 2016 Jan;37(1):17-36. doi: 10.1016/j.tips.2015.09.003.

Hot Papers of Spring-Summer 2015

• Villa F, Carrizzo A, Spinelli CC, et al. Genetic analysis reveals a longevity-associated protein modulating endothelial function and angiogenesis. Circ Res. 2015;117:333–345.
• Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias P-T, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KB, Stamler J and Ichinose F. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy Circ Res. August 10, 2015. doi: 10.1161/CIRCRESAHA.115.307157
• Mishanina TV, Libiad M, Banerjee R. Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways. Nat Chem Biol. 2015;11:457-64.
• Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015;8:ra37.
• Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14:329-45.
• Cortese-Krott MM, Kuhnle GG, Dyson A, Fernandez BO, Grman M, DuMond JF, Barrow MP, McLeod G, Nakagawa H, Ondrias K, Nagy P, King SB, Saavedra JE, Keefer LK, Singer M, Kelm M, Butler AR, Feelisch M. Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl. Proc Natl Acad Sci U S A. 2015 Jul 29. pii: 201509277. [Epub ahead of print]
• Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. J Am Coll Cardiol. 2015;66:154-65.

 Hot papers of September-December 2014

• Zhu LJ, Li TY, Luo CX, Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY, Ma Y, Zhou QG, Hu Q, Hu XL, Zhang J, Wu HY,Zhu DY. CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014;20(9):1050-4. doi: 10.1038/nm.3644.
• Gill AJ, Kovacsics CE, Cross SA, Vance PJ, Kolson LL, Jordan-Sciutto KL, Gelman BB, Kolson DL. Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders. J Clin Invest. 2014;124(10):4459-72. doi: 10.1172/JCI72279.
• Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine. Proc Natl Acad Sci U S A. 2014;111(37):E3845-52. doi: 10.1073/pnas.1414545111.
• Elies J, Scragg JL, Huang S, Dallas ML, Huang D, MacDougall D, Boyle JP, Gamper N, Peers C. Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels. FASEB J. 2014;28(12):5376-87. doi: 10.1096/fj.14-257113. 
• Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation. J Clin Invest. 2014;124(11):4926-40. doi: 10.1172/JCI72853.
• Tawfik A, Markand S, Al-Shabrawey M, Mayo JN, Reynolds J, Bearden SE, Ganapathy V, Smith SB. Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia. Am J Pathol. 2014;184(9):2573-85. doi: 10.1016/j.ajpath.2014.05.018.
• Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J, Kasperaviciute D, Bhosle SG, Mueller M, Geschka S, Rison S, Kojonazarov B, Morrell NW, Neidhardt I, Surmeli NB, Aitman TJ, Stasch JP, Behrends S, Marletta MA. α1-A680T Variant in GUCY1A3 as a Candidate Conferring Protection From Pulmonary Hypertension AmongKyrgyz Highlanders. Circ Cardiovasc Genet. 2014;7(6):920-9. doi: 10.1161/CIRCGENETICS.114.000763.
• Vasas A, Dóka É, Fábián I, Nagy P. Kinetic and thermodynamic studies on the disulfide-bond reducing potential of hydrogen sulfide. Nitric Oxide. 2014 Dec 12. pii: S1089-8603(14)00510-2. doi: 10.1016/j.niox.2014.12.003.
• Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias P, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA. The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction. Circulation. 2014 Dec 22. pii: CIRCULATIONAHA.114.012957.
• Hu Y, Li R, Yang H, Luo H, Chen Z. Sirtuin 6 Is Essential for Sodium Sulfide-mediated Cytoprotective Effect in Ischemia/Reperfusion-Stimulated Brain Endothelial Cells. J Stroke Cerebrovasc Dis. 2014. pii: S1052-3057(14)00505-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.10.006.
• Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits. Cell. 2014 Dec 23. pii: S0092-8674(14)01525-6. doi: 10.1016/j.cell.2014.11.048.

Hot Papers of the month July-August 2014

• Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ. Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content. J Biol Chem. 2014 May 30;289(22):15259-71. doi: 10.1074/jbc.M114.559393.
• Steiger C, Lühmann T, Meinel L. Oral drug delivery of therapeutic gases - Carbon monoxide release for gastrointestinal diseases.J Control Release. 2014 Jun 24;189C:46-53. doi: 10.1016/j.jconrel.2014.06.025. 
• Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR. H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381
• Lavin B, Gómez M, Pello OM, Castejon B, Piedras MJ, Saura M, Zaragoza C. Nitric Oxide Prevents Aortic Neointimal Hyperplasia by Controlling Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1739-46. doi: 10.1161/ATVBAHA.114.303866. 
• Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014 Jun 2;124(6):2464-71. doi: 10.1172/JCI70731.
• Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, Vigneshwar N, Mukhopadhyay ND, Kukreja RC, Abbate A, Salloum FN.Induction of MicroRNA-21 With Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice. Circ Cardiovasc Genet. 2014 Jun;7(3):311-20. doi: 10.1161/CIRCGENETICS.113.000381. 
• Xie ZZ, Shi MM, Xie L, Wu ZY, Li G, Hua F, Bian JS. Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide. Antioxid Redox Signal. 2014 Jun 26.
• Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7606-11. doi: 10.1073/pnas.1321232111. 
• Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E, Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide O, Tadele E, Brandes RP, Grimminger J, Klepetko W, Jaksch P, Rodriguez-Roisin R, Seeger W, Grimminger F, Barberà JA. Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema.Am J Respir Crit Care Med. 2014 Jun 1;189(11):1359-73. doi: 10.1164/rccm.201311-2037OC.

Hot papers of the month April/May 

• Lu Y, Yu T, Liang H, Wang J, Xie J, Shao J, Gao Y, Yu S, Chen S, Wang L, Jia L. Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade.Sci Rep. 2014 Mar 11;4:4344. doi: 10.1038/srep04344.
• Patenaude A1, Fuller M, Chang L, Wong F, Paliouras G, Shaw R, Kyle AH, Umlandt P, Baker JH, Diaz E, Tong J, Minchinton AI, Karsan A. Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism. Cancer Res. 2014 Mar 5.
  
• Bucci M, Vellecco V, Cantalupo A, Brancaleone V, Zhou Z, Evangelista S, Calderone V, Papapetropoulos A, Cirino G. Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.Cardiovasc Res. 2014 Feb 19. 
• Du J, Huang Y, Yan H, Zhang Q, Zhao M, Zhu M, Liu J, Chen SX, Bu D, Tang C, Jin H. Hydrogen sulfide suppresses ox-LDL-stimulated monocyte chemoattractant protein-1 generation from macrophages via NF-κB pathway.J Biol Chem. 2014 Feb 18. 
• Hervé D, Philippi A, Belbouab R, Zerah M, Chabrier S, Collardeau-Frachon S, Bergametti F, Essongue A, Berrou E, Krivosic V, Sainte-Rose C, Houdart E, Adam F, Billiemaz K, Lebret M, Roman S, Passemard S, Boulday G, Delaforge A, Guey S, Dray X, Chabriat H, Brouckaert P, Bryckaert M, Tournier-Lasserve E. Loss of α1β1 Soluble Guanylate Cyclase, the Major Nitric Oxide Receptor, Leads to Moyamoya and Achalasia.Am J Hum Genet. 2014 Feb 25. pii: S0002-9297(14)00056-1. doi: 10.1016/j.ajhg.
  
• Gupta S, Melnyk SB, Kruger WD. Cystathionine β-synthase-deficient mice thrive on a low-methionine diet.FASEB J. 2014 Feb;28(2):781-90. doi: 10.1096/fj.13-240770. 
• Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):626-34. doi: 10.1161/ATVBAHA.113.302576. 
• Cortese-Krott MM, Fernandez BO, Santos JL, Mergia E, Grman M, Nagy P, Kelm M, Butler A, Feelisch M. Nitrosopersulfide (SSNO(-)) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide.Redox Biol. 2014 Jan 11;2:234-44. doi: 10.1016/j.redox.2013.12.031. 
• Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta MA. Nitric Oxide-Induced Conformational Changes in Soluble Guanylate Cyclase.Structure. 2014 Feb 18. pii: S0969-2126(14)00018-5. doi: 10.1016/j.str.2014.01.008.

Hot papers of the month January/February

• Tong G, Aponte AM, Kohr MJ, Steenbergen C, Murphy E, Sun J.Postconditioning leads to an increase in protein S-nitrosylation.Am J Physiol Heart Circ Physiol. 2014 Jan 17. PMID: 24441547 
• Ferlito M, Wang Q, Fulton WB, Colombani PM, Marchionni L, Fox-Talbot K, Paolocci N, Steenbergen C. H2S Increases Survival During Sepsis: Protective Effect of CHOP Inhibition. J Immunol. 2014 Jan 8. [Epub ahead of print]
• Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 6.PMID: 24395806 
• Zhang D, Macinkovic I, Devarie-Baez NO, Pan J, Park CM, Carroll KS, Filipovic MR, Xian M. Detection of Protein S-Sulfhydration by a Tag-Switch Technique.Angew Chem Int Ed Engl. 2013 Nov 29. doi: 10.1002/anie.201305876. [Epub ahead of print]
• Abid S, Houssaïni A, Mouraret N, Marcos E, Amsellem V, Wan F, Dubois-Randé JL, Derumeaux G, Boczkowski J, Motterlini R, Adnot S. p21-Dependent Protective Effects of a Carbon Monoxide-Releasing Molecule-3 in Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2013 Dec 12. [Epub ahead of print]
• Ghebremariam YT, Erlanson DA, Cooke JP. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76. doi: 10.1124/jpet.113.206847. Epub 2013 Oct 17.

• Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression. Biochem J. 2013 Dec 12. [Epub ahead of print]

• Xue J, Habtezion A. Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest. 2014 Jan 2;124(1):437-47. doi: 10.1172/JCI71362. Epub 2013 Dec 16.

Hot Papers of the Month -November/December

• Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Esk S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Braenne I, Noethen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, Maerz W, Reily M, Kathiresan S, McPherson R, Walter U, Cardiogram, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013 Nov 10. doi: 10.1038/nature12722. [Epub ahead of print]
• d'Emmanuele di Villa Bianca R, Mitidieri E, Di Minno MN, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R. Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15812-7.doi: 10.1073/pnas.1309049110.
• Ereño-Orbea J, Majtan T, Oyenarte I, Kraus JP, Martínez-Cruz LA. Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3790-9. doi: 10.1073/pnas.1313683110. 
• Peter EA, Shen X, Shah SH, Pardue S, Glawe JD, Zhang WW, Reddy P, Akkus NI, Varma J, Kevil CG. Plasma free H2S levels are elevated in patients with cardiovascular disease. J Am Heart Assoc. 2013 Oct 23;2(5):e000387. doi: 10.1161/JAHA.113.000387.
• Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5. doi: 10.1073/pnas.1306942110. 
• Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. Convergence of g protein-coupled receptor and s-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.

Hot Papers of the Month -September/October

• Lies B, Groneberg D, Gambaryan S, Friebe A. Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase. Br J Pharmacol. 2013 Jun 14. doi: 10.1111/bph.12275. [Epub ahead of print]
• Thunemann M, Wen L, Hillenbrand M, Vachaviolos I-A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R. Transgenic Mice for cGMP Imaging. Circ Res. 2013;113(4):365-71. doi: 10.1161/CIRCRESAHA.113.301063. 
• Hull TD, Bolisetty S, Dealmeida AC, Litovsky SH, Prabhu SD, Agarwal A, George JF. Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase. Lab Invest. 2013;93(8):868-79. doi: 10.1038/labinvest.2013.74.
• Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, Hellmich MR. Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Proc Natl Acad Sci U S A. 2013;110(30):12474-9. doi: 10.1073/pnas.1306241110. 
• Teng H, Wu B, Zhao K, Yang G, Wu L, Wang R. Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease. Proc Natl Acad Sci U S A. 2013;110(31):12679-84. doi: 10.1073/pnas.1308487110. 
• Hannah E. Boycott, Mark L. Dallas, Jacobo Elies, Louisa Pettinger, John P. Boyle, Jason L. Scragg, Nikita Gamper, and Chris Peers. Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin. FASEB J. 2013; 27:3395-3407 doi:10.1096/fj.13-227249
• Heinrich TA, da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM. Biological nitric oxide signalling: chemistry and terminology. Br J Pharmacol. 2013;169(7):1417-29. doi: 10.1111/bph.12217.

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  Hot Papers of the Month- June/July

• Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, Baily J, Miller MR, Cudmore M, Hadoke PW, Wang R, Gratacós E, Buhimschi IA, Buhimschi CS, Ahmed A. Dysregulation of Hydrogen Sulfide (H2S) Producing Enzyme Cystathionine γ-lyase (CSE) Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia. Circulation. 2013 May 23. [Epub ahead of print]
• Margaritis M, Antonopoulos AS, Digby J, Lee R, Reilly S, Coutinho P, Shirodaria C, Sayeed R, Petrou M, De Silva R, Jalilzadeh S, Demosthenous M, Bakogiannis C, Tousoulis D, Stefanadis C, Choudhury RP, Casadei B, Channon KM, Antoniades C. Interactions Between Vascular Wall and Perivascular Adipose Tissue Reveal Novel Roles for Adiponectin in the Regulation of Endothelial Nitric Oxide Synthase Function in Human Vessels. Circulation. 2013;127:2209-2221. doi: 10.1161/CIRCULATIONAHA.112.001133
• Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. doi: 10.1073/pnas.1219997110.
• Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D.NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013;123(4):1718-31.
• Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM. Ubiad1 is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 2013;152(3):504-18. doi: 10.1016/j.cell.2013.01.013.
• Basuroy S, Leffler CW, Parfenova H. CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis. Am J Physiol Cell Physiol. 2013;304(11):C1105-15. doi: 10.1152/ajpcell.00023.2013.
• Kimura Y, Mikami Y, Osumi K, Tsugane M, Oka JI, Kimura H. Polysulfides are possible H2S-derived signaling molecules in rat brain. FASEB J. 2013; 27:2451-2457 doi:10.1096/fj.12-226415
• Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med. 2013 May 26. doi: 10.1038/nm.3212. [Epub ahead of print]
• Greiner R, Palinkas Z, Bäsell K, Becher D, Antelmann H, Nagy P, Dick TP. Polysulfides link H2S to protein thiol oxidation. Antioxid Redox Signal. 2013 May 7. [Epub ahead of print]

 Hot papers of the month March/April

• Katakam P,Wappler E, Katz P, Rutkai I, Institoris A, Domoki F, Gáspár T, Grovenburg SM, Snipes JA, Busija DW. Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Vascular Vasodilation by Activation of Nitric Oxide Synthase. Arterioscler Thromb Vasc Biol.2013 Jan 17 [Epub ahead of print]. doi:10.1161/ATVBAHA.112.300560
• Makita N,  Kabasawa Y,  Otani Y, Firman, Sato J, Hashimoto M, Nakaya M, Nishihara H,  Nangaku M, Kurose H, Ohwada T, Iiri T. Attenuated Desensitization of β-Adrenergic Receptor by Water-Soluble N-Nitrosamines That Induce S-Nitrosylation Without NO Release. Circulation Research.2013; 112:327-334. doi: 10.1161/CIRCRESAHA.112.277665
• Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 Is Essential for Sodium Sulfide–Mediated Cardioprotection in the Setting of Heart Failure. Arterioscler Thromb Vasc Biol.2013 Jan 24[Epub ahead of print].doi: 10.1161/ATVBAHA.112.300484
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