Prof. Dr. Ulrich Schatzschneider

Associate Professor of Bioinorganic Chemistry 
Institut für Anorganische Chemie 
Julius-Maximilians-Universität Würzburg  Am Hubland
D-97074 Würzburg
Germany

Tel (0)49-931-31-83636
Fax (0)49-931-31-84605
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http://www-anorganik.chemie.uni-wuerzburg.de/schatzschneider

Research Interests
The main focus of work in the Schatzschneider group in the field of  bioorganometallic and medicinal inorganic chemistry is to utilize the  inherent properties of transition metal compounds, like redox activity,  light absorption and emission, as well as ligand exchange reactions to  develop novel diagnostic and therapeutic agents with potential  applications in human medicine.

In our major project, novel transition-metal carbonyl complexes are  prepared and evaluated for their applications as CO-releasing molecules  (CORMs), in particular those which can be induced by external stimuli  like enzymatic reactions (ET-CORMs) and photoactivation (PhotoCORMs).

Significant work is also devoted to the attachment of such CORMs to  biological carrier systems like cell-penetrating peptides (CPPs) and  nanoparticles for selective enrichment in cells and tissues.

Selected Recent Publications

• G. Dördelmann, H. Pfeiffer, A. Birkner, U. Schatzschneider,  "Silicium dioxide nanoparticles as carriers for photoactivatable CO  releasing molecules (PhotoCORMs)", Inorg. Chem. 2011, 50, 4362-4367.
• S. Romanski, B. Kraus, U. Schatzschneider, J.-M. Neudörfl, S.
  Amslinger, H.-G. Schmalz, "Acyloxy-butadiene-Fe(CO)3 Complexes as  Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)", Angew. Chem. Int.
  Ed. 2011, 50, 2392-2396.
• H. Pfeiffer, A. Rojas, J. Niesel, U. Schatzschneider, "Sonogashira  and "Click" reactions in the N-terminal and side chain functionalization  of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm =  tris(pyrazolyl)methane)", Dalton Trans. 2009, 4292-4298.