Prof. Santiago Lamas
Deparment of Cell Biology and Immunology
Centro de Biología Molecular “Severo Ochoa”( CBMSO)
Consejo Superior de Investigaciones Cientificas (CSIC).
Nicolás Cabrera, 1.
Our group investigates the molecular, biochemical, and cellular mechanisms that underlie the pathophysiology of the vascular wall. We have a fundamental interest in the endothelial response to oxidative and nitrosative stress through specific posttranslational modifications such as S-glutathionylation, S-nitrosylation and tyrosine nitration as well as redox signaling in endothelial cells. We are also interested in the role of the TGF-endothelin-1 axis in fibrosis as this is a pathology inherently related to endothelial dysfunction. Finally, another aim of our group is to find new antiangiogenic strategies in order to halt tumor growth.
Selected Recent Publications
- Nitric oxide signaling: classical, less classical, and nonclassical mechanisms. Martínez-Ruiz A, Cadenas S, Lamas S. Free Radic Biol Med 51:17-29, 2011.
- Cyclosporine A-Induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas S. Cardiovasc Res 87:356-65, 2010.
- Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Rodríguez-Pascual F, Redondo-Horcajo M, Magán-Marchal N, Lagares D, Martínez-Ruiz A, Kleinert H, Lamas S. Mol Cell Biol 28:7139-55, 2008.