Romain Lefebvre, MD, PhD

Professor & Chair
Heymans Institute of Pharmacology
Faculty of Medicine and Health Sciences
Ghent University
De Pintelaan 185
B-9000 Gent
Belgium
Email : This email address is being protected from spambots. You need JavaScript enabled to view it.
Tel : 32-9-3323373
Fax : 32-9-3324988

Research Interests

• Mechanisms of action of gaseous messengers in influencing gastrointestinal motility.
• Role of soluble guanylate cyclase (sGC) isoforms α1β1 and α2β1 , of NO-dependent versus NO-independent functions of sGC and of sGC-dependent versus sGC-independent effects of NO in gastrointestinal motility and inflammation.
• Mechanism of the anti-inflammatory and anti-oxidative effects of heme oxygenase-derived products in the gastrointestinal tract.
• Role of cyclic nucleotides in signal transduction of 5-HT4 receptor activation in stomach, colon and heart.

 

Selected Recent Publications

• Vanneste G., Dhaese I., Sips P., Buys E., Brouckaert P., Lefebvre R.A. : Gastric motility in soluble guanylate cyclase alfa 1 knock-out mice. J. Physiol. 2007, 584, 907-920.
• De Backer O., Elinck E., Blanckaert B., Leybaert L., Motterlini R., Lefebvre R.A. : Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress. Gut, 2009, 58, 347-356.
• Dhaese I., Van Colen I., Lefebvre R.A. : Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle. Eur. J. Pharmacol. 2010, 628, 179-186.